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Ropivacaine hydrochloride

Name: Ropivacaine hydrochloride
Brand: TargetMol
SKU: T0386
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0386Cas No. 98717-15-8

Alias Ropivacaine monohydrochloride

Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.

Ropivacaine hydrochloride

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Purity: 99.95%

Catalog No. T0386Alias Ropivacaine monohydrochlorideCas No. 98717-15-8

Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$48	In Stock	In Stock
50 mg	$63	In Stock	In Stock
100 mg	$92	In Stock	In Stock
200 mg	$133	In Stock	In Stock
500 mg	$226	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Ropivacaine hydrochloride AI Summary

Ropivacaine hydrochloride exhibits diverse bioactivities. It inhibits HP1-beta chromodomain interactions with methylated histone tails (potency of 100000.0 nM) and induces DNA re-replication in MCF 10a normal breast cells (potency of 920.0 nM). Additionally, it inhibits the ERG Ets/DNA interaction (potency of 11220.2 nM), human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 23715.0 nM, and shows cytotoxicity against HeLa cells (AC50 > 52000.0 nM). Ropivacaine hydrochloride also blocks Ebola virus entry in green and blue channel screens (AC50 of 39810.7 nM and 5011.9 nM, respectively) and affects insulin secretion from INS-1E cells in the presence of 5 mM glucose (IC50 of 33330.0 nM). The compound shows low activity against SARS-CoV-2 infected Vero E6 cells, with an inhibition index of 0.08355 compared to arbidol control. Despite weak inhibition percentages against SARS-CoV-2 induced cytotoxicity of Caco-2 cells (-0.23% at 10 µM after 48 hours) and VERO-6 cells (0.06% at 10 µM after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus), it demonstrates minimal antiviral efficacy. It also shows -2.417% inhibition against SARS-CoV-2 3CL-Pro protease at 20 μM. Ropivacaine hydrochloride exhibits moderate antifungal and antibacterial activities. It inhibits the growth of Candida albicans and Cryptococcus neoformans by 3.24% and -6.59% respectively, and shows activity against bacteria: Escherichia coli (1.04%), Klebsiella pneumoniae (12.03%), Pseudomonas aeruginosa (18.3%), Acinetobacter baumannii (26.89%), and Staphylococcus aureus MRSA (13.36%)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity.
Targets&IC50	K+ channel (TREK-1):402.7 μM
Synonyms	Ropivacaine monohydrochloride

Chemical Properties

Molecular Weight	310.86
Formula	C₁₇H₂₆N₂O·HCl
Cas No.	98717-15-8
Smiles	Cl.CCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C
Relative Density.	1.044 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11.9 mg/mL (38.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2169 mL	16.0844 mL	32.1688 mL	160.8441 mL
5 mM	0.6434 mL	3.2169 mL	6.4338 mL	32.1688 mL
10 mM	0.3217 mL	1.6084 mL	3.2169 mL	16.0844 mL
20 mM	0.1608 mL	0.8042 mL	1.6084 mL	8.0422 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc